Patriots haven't been this big an underdog since they beat Rams in Super Bowl (Shutdown Corner)

Apparently the New England Patriots being without Tom Brady, Rob Gronkowski and two starting offensive linemen means something to Las Vegas. The Patriots are now listed as huge underdogs against the Arizona Cardinals, getting the most points in franchise history in more than 13 years. The Patriots are 9.5-point underdogs against the Cardinals tonight.
Source: Yahoo.com