NFL 2016: Jets, Dolphins, Bills take aim at Patriots' throne (The Associated Press)

The last time the New England Patriots opened a season without Tom Brady under center, few could have imagined what the young quarterback would become. It was 2001, when Drew Bledsoe started the first two games before suffering a serious chest injury – opening the door for a second-year quarterback from Michigan drafted 199th overall. Brady led the Patriots to a Super Bowl victory that season, the first of four titles so far that he and coach Bill Belichick have won with New England.
Source: Yahoo.com